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The Paal–Knorr Synthesis in organic chemistry is a reaction that generates either furans, pyrroles, or thiophenes from 1,4-diketones. It is a synthetically valuable method for obtaining substituted furans and pyrroles, common structural components of many natural products. It was initially reported independently by German chemists Carl Paal and Ludwig Knorr in 1884 as a method for the preparation of furans, and has been adapted for pyrroles and thiophenes. Although the Paal–Knorr synthesis has seen widespread use, the mechanism wasn't fully understood until it was elucidated by V. Amarnath ''et al.'' in the 1990s. The furan synthesis requires an acid catalyst: : In the pyrrole synthesis a primary amine participates: : and in that of thiophene for instance the compound phosphorus pentasulfide: : ==Mechanisms== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Paal–Knorr synthesis」の詳細全文を読む スポンサード リンク
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